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Current Research in Nutrition and Food Science - An open access, peer reviewed international journal covering all aspects of Nutrition and Food Science

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The Effectiveness of Aloe-based Drink in Reducing Glycated Albumin and Insulin Resistance of Metabolic Syndrome: A Randomized Clinical Trial


Rizki Widyan Aisya1, K. Heri Nugroho H.S2, Nyoman Suci Widyastiti3, Kusmiyati-Tjahjono4 and Diana Nur Afifah1*


1Department of Nutrition Science, Faculty of Medicine, Diponegoro University,
Semarang, Indonesia.

2Department of Internal Medicine, Faculty of Medicine, Diponegoro University,
Semarang, Indonesia.

3Department of Clinical Pathology, Faculty of Medicine, Diponegoro University,
Semarang, Indonesia.

4Department of Biochemistry, Faculty of Medicine, Diponegoro University,
Semarang, Indonesia.

Corresponding Author Email: d.nurafifah.dna@fk.undip.ac.id


Abstract:

Insulin resistance (IR) has an important role in the pathology that forms the metabolic syndrome (MetS). Glycated Albumin (GA) has a role as an index of glycemic control associated with MetS. Aloe vera (Aloe barbadensis Miller) is a plant that has anti-diabetic and anti-hypercholesterolemic function. This study aims to investigate the effect of Aloe-based drink on GA and IR in MetS. This study was a true experimental using pre-post randomized control group design. Thirty-eight MetS subjects were divided into two groups: treatment group (n=19) which was provided by 165 g/d of Aloe-based drink for 4 weeks; and the control group (n=19). Both groups were given education regarding of management of MetS. GA was measured by using an ELISA method and IR calculated by HOMA-IR of both groups and statistically analyzed at baseline and the end of treatment. The data were analyzed using paired t-test and independent t-test. At the end of the study, the treatment group showed reduction of GA and HOMA-IR statistically significant (∆GA=-4.3±2.35%; ∆HOMA-IR=-1.6 ±1.87; p=0.001). Compared to control group, the change of GA and HOMA-IR in intervention group were also significantly different. Aloe-based drink was proven to reduce GA and IR in the MetS.


Keywords:

Aloe-Based Drink; Glycated Albumin; Insulin Resistance; Metabolic Syndrome


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