Inflammation is a reaction to a disrupted tissue homeostasis. Basically it is a tissue-destroying process that involves the recruitment of blood-derived products. Rapidly destroy or isolate the underlying source of the disturbance, removes damaged tissue and restore tissue homeostasis is the primary function of inflammation. Inflammatory and chronic metabolic alterations that together are termed metabolic syndrome. The risk of developing serious pathological conditions such as cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD) is significantly associated with inflammation and its concurrent multi-organ abnormalities which represent a great burden upon societies, as they require significant resources from health care systems. Thus, understanding the tissue-specific pathogenic processes that lead to disease progression is required for the development of more effective therapeutic approaches.