Personalized Nutrition means in practice, adapting food to individual needs, depending on the host’s genome, this calls for an emerging field of nutrigenomic approach in order to build the tools for individualized diet, health maintenance and disease prevention. Based on this principle, breast milk is now being analyzed, modified and administered in smaller infants to provide them personalized diet, ensuring the premature infants are receiving correct amounts of nutrients they need to thrive. In the past, all milk was fortified to the same and it was ‘one-size-fits-all’. Now, nutrigenomics is moving towards having the ability to personalize each mother’s milk to give her baby precise nutrition he needs by stressing upon nutrition and interaction of three health  relevant genomes in perspective, namely the food, the gut microbial and the human host genome in context of individualized nutrition and optimum health.