eng Enviro Research Publishers Current Research in Nutrition and Food Science Journal 2347-467X 2322-0007 2025-03-25 13 1 24 45 10.12944/CRNFSJ.13.1.2 22762 article Mohsineen Wazir 1 Hemant Verma 2 Jyoti Singh 1 Prerna Singh 1 Sarita Passey 1 Department of Chemistry, Zakir Husain Delhi College: University of Delhi, India Department of Chemistry, Hindu College; University of Delhi, India. In today's world, low-calorie sweeteners are essential due to the growing demand for alternatives to sugar, driven by rising health concerns such as obesity, diabetes, and metabolic disorders. They provide sweetness without the adverse effects of excessive sugar consumption, making them useful in foods, beverages, and dietary products. Natural sweeteners are increasingly favoured over artificial ones because they offer similar sweetness with added health benefits, such as antioxidant properties, without synthetic chemicals. Their natural origins and minimal impact on blood sugar make them a preferred choice for health-conscious consumers. This article explores and compares two popular natural sweeteners, Monk fruit and Stevia, across multiple dimensions. Monk fruit, derived from the fruit of Siraitia grosvenorii, has been used for centuries in traditional Chinese medicine. Stevia, obtained from the leaves of the Stevia rebaudiana plant, has a similar historical use in South America. The safety concerns, extraction processes, metabolic pathways and interaction with gut microbiota of both the sweeteners have been discussed in detail. The article also highlights, how both these natural sweeteners are processed in the body without contributing to calorie intake, making them suitable for individuals with diabetes and those seeking weight management options. Furthermore, the health effects associated with each sweetener have been explored. This comprehensive comparison aims to guide consumers and food manufacturers in making informed choices about these two natural sweeteners. https://www.foodandnutritionjournal.org/volume13number1/the-battle-of-natural-sweeteners-a-comprehensive-guide-to-monk-fruit-and-stevia/ Alternatives  Artificial Calorie intake Health effects Natural Sweeteners