eng Enviro Research Publishers Current Research in Nutrition and Food Science Journal 2347-467X 2322-0007 2026-03-31 14 Special Issue Sustainable Nutrition February 2026 25738 article Rahul Kumar 1 Mohammad Aves 2 Hargun Kaur 1 Department of Microbiology, Graphic Era (Deemed to be University), Dehradun, India Department of Computer Science and Engineering, Graphic Era (Deemed to be University), Dehradun, India Neuro-inflammation is a major pathological feature that is responsible for a variety of neurologic and psychobiotic conditions like Parkinsosn’s, Alzheimer’s, multiple sclerosis, depression, and cognitive impairment. The growing body of research suggests that nutrition can significantly influence Neuro-inflammation processes through its effects on the regulation of the immune system, the generation of free radicals, the health of the metabolism, and signaling in the gut-brain axis. This review summarizes the present knowledge regarding the dietary management of Neuro-inflammation, especially focusing on the pathways of the mechanisms through which this occurs, the support of preclinical and clinical studies, and the implications for public health. An even wider range of dietary patterns and nutrients, among which are the omega-3 fatty acids, polyphenols, dietary fiber, vitamins, and minerals, are discussed regarding their impact on microglial activation, inflammatory cytokine production, and neuroprotective signaling pathways. The record further addresses the function of intestinal microbiota as player in the Neuro-inflammation reactions triggered by diet. The paper showcases the potential of artificial intelligence and machine learning in nutritional neuroscience with applications such as dietary pattern analysis, biomarker discovery, and customized nutrition methods. When looking at public health, food based interventions are seen as cost-effective, scalable ways to get rid of the Neuro-inflammation burden and keep the brain healthy at the level of the population. The review also points out the existing shortcomings, the areas of research that need to be filled, and the ethical considerations that are always there, and stresses the need for standardized biomarkers, longitudinal studies, and equal access to nutritious foods. In general, the combination of nutrition strategies and digital technologies in public health systems for the treatment of Neuro-inflammation and the improvement of neurological outcomes has great potential. https://www.foodandnutritionjournal.org/vol14nospl-issue-sustainable-nutrition-2026/nutritional-regulation-of-neuro-inflammation-mechanisms-evidence-and-public-health-benefits/ Diet and brain health Microbiota Public health nutrition Polyphenols Precision nutrition