eng Enviro Research Publishers Current Research in Nutrition and Food Science Journal 2347-467X 2322-0007 2025-07-10 13 Special Issue Phytonutrients July 2025 53 71 10.12944/CRNFSJ.13.Special-Issue-July.04 23687 article Rahul Kumar 1 Neha Kamboj 1 Divya Gunsola 1 Rachan Karmakar 2 Sourav Chattaraj 3 Saurabh Gangola 1 Department of Microbiology, Graphic Era (Deemed to be University), Dehradun, Uttarakhand, India Department of Environmental Science, Graphic Era (Deemed to be University), Dehradun, Uttarakhand, India Centre for Industrial Biotechnology Research, School of Pharmaceutical Science, Siksha ‘O’ Anusandhan University, Bhubaneswar, Odisha, India Department of Biotechnology, Graphic Era (Deemed to be University), Dehradun, Uttarakhand, India Department of Agriculture Engineering, Baba Banda Singh Bahadur Engineering College, Fatehgarh Sahib India 6Department of Biotechnology, Invertis University, Bareilly, Lucknow, Uttar Pradesh, India Bioactive compounds known as phytonutrients, which are abundant in fruits, vegetables, whole grains, and herbs, have indicated great potential in the war against cancer and chronic inflammation. Epidemiological studies have consistently demonstrated that high-phytonutrient diets are associated with a 30–40% reduced risk for chronic diseases, including heart disease and various forms of cancer. The methodology used in this review like search tools google scholar, PubMed, and science direct for data review. Notable anti-inflammatory and anti-cancer effects have been shown by flavonoids, carotenoids, glucosinolates, phenolic acids, and stilbenes, among others. Sulforaphane, a derivative of glucosinolate, inhibits histone deacetylase (HDAC) activity linked with tumor growth, while quercetin and curcumin reduce pro-inflammatory cytokines (IL-6, TNF-α) by over 50% in vitro. Resveratrol has already been demonstrated to decrease tumor mass by 60–70% in animal models through the modification of the NF-κB and PI3K/AKT pathways. However, challenges such as low bioavailability and metabolic instability limit clinical translation despite positive preclinical results. Enhanced three- to tenfold bioavailability has been exhibited by recent nanoformulation innovations, providing fresh therapeutic application avenues. The mechanisms through which phytonutrients exhibit anti-inflammatory and anti-cancer effects are well discussed in this review, which also points out quantitative outcomes of in vitro, in vivo, and clinical trials and discusses innovations to bypass delivery problems. Ultimately, the incorporation of phytonutrients into treatment regimens and preventative health programs could be vital to reducing the occurrence of cancer and disorders associated with inflammation globally. https://www.foodandnutritionjournal.org/vol13nospl-issue-phytonutrients-2025/phytonutrients-harnessing-anti-inflammatory-and-anti-cancer-potential-for-health-benefits/ Anti-inflammatory Bioavailability Curcumin Flavonoids Resveratrol Phytonutrients